rs1052133
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Xeroderma Pigmentosum, Complementation Group D
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0.050 |
GeneticVariation
|
BEFREE |
Our results indicate that SNPs in the NER genes ERCC1 (Asn118Asn, 15310G>C, 8902G>T), XPA (-4G>A), ERCC2/XPD (Lys751Gln) and ERCC5/XPD (His46His); the BER genes APE1/APEX (Ile64Val), OGG1 (Ser326Cys), PCNA (1876A>G) and XRCC1 (Arg194Trp, Arg280His, Arg399Gln); and the DSB-R genes ATR (Thr211Met), NBS1 (Glu185Gln), XRCC2 (Arg188His) and XRCC9 (Thr297Ile) modulate NSCLC risk.
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16195237 |
2006 |
rs1052133
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Xeroderma Pigmentosum, Complementation Group D
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0.050 |
GeneticVariation
|
BEFREE |
In the present study, we investigated the polymorphisms of following selected DNA repair genes: XPC (Lys939Gln), XPD (Lys751Gln), hOGG1 (Ser326Cys) and XRCC1 (Arg399Gln), and the risks they present towards the development of lung cancer with the emphasis to gender differences within the Slovak population.
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23673479 |
2013 |
rs1052133
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Xeroderma Pigmentosum, Complementation Group D
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0.050 |
GeneticVariation
|
BEFREE |
We observed a strong association between breast cancer occurrence and the genotypes C/C of the RAD51-135G/C polymorphism, Ser/Ser of the OGG1-Ser326Cys and Lys/Gln of the XPD-Lys751Gln, whereas the genotypes G/C of the RAD51-135G/C and Lys/Lys of the XPD-Lys751Gln exerted a protective effect against breast cancer.
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18977234 |
2008 |
rs1052133
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Xeroderma Pigmentosum, Complementation Group D
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0.050 |
GeneticVariation
|
BEFREE |
The present meta-analysis has limited evidence to support the association of XPD Lys751Gln and hOGG1 Ser326Cys polymorphisms with HCC risk.
|
23271362 |
2013 |
rs1052133
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Xeroderma Pigmentosum, Complementation Group D
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0.050 |
GeneticVariation
|
BEFREE |
We investigated the effect of hOGG1 (Ser326Cys) and XPD (Lys751Gln) polymorphisms on the oxidative stress level after reperfusion.
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22194171 |
2011 |
rs1052133
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XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C
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|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we investigated the polymorphisms of following selected DNA repair genes: XPC (Lys939Gln), XPD (Lys751Gln), hOGG1 (Ser326Cys) and XRCC1 (Arg399Gln), and the risks they present towards the development of lung cancer with the emphasis to gender differences within the Slovak population.
|
23673479 |
2013 |
rs1052133
|
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Varicocele
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0.010 |
GeneticVariation
|
BEFREE |
The hOGG1 Ser326Cys polymorphism and male subfertility in Taiwanese patients with varicocele.
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29582449 |
2018 |
rs1052133
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Triple-Negative Breast Carcinoma
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0.010 |
GeneticVariation
|
BEFREE |
No significant associations between Ser326Cys and Arg194Trp genotype and TNBC were observed.
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24402573 |
2014 |
rs1052133
|
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Triple Negative Breast Neoplasms
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0.010 |
GeneticVariation
|
BEFREE |
No significant associations between Ser326Cys and Arg194Trp genotype and TNBC were observed.
|
24402573 |
2014 |
rs1052133
|
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Tooth Loss
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0.010 |
GeneticVariation
|
BEFREE |
In addition, a multivariate logistic regression analysis in which age, gender, body mass index (BMI), and ischemic heart disease were included as independent variables indicated that Ser326Cys could be an independent factor affecting tooth loss (OR, 3.191; 95%CI, 1.174-8.672).
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16538639 |
2006 |
rs1052133
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Subfertility, Male
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0.010 |
GeneticVariation
|
BEFREE |
The hOGG1 Ser326Cys polymorphism and male subfertility in Taiwanese patients with varicocele.
|
29582449 |
2018 |
rs1052133
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Stomach Carcinoma
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0.100 |
GeneticVariation
|
BEFREE |
Polymorphic variants of base excision repair (APE1-D148E, XRCC1-R194W, XRCC1-R399Q and OGG1-S326C), nucleotide excision repair (XPC-PAT, XPA-23G>A, ERCC1-19007T>C and XPD-L751Q), recombination (XRCC3-T241M) and alkylation damage reversal (MGMT-L84F) were tested for their potential role in the development of GC by using logistic regression models.
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20817763 |
2010 |
rs1052133
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Stomach Carcinoma
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0.100 |
GeneticVariation
|
BEFREE |
Taken together, the results suggest that the hOGG1 Ser326Cys polymorphism may contribute to susceptibility to gastric cancer.
|
22343785 |
2012 |
rs1052133
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Stomach Carcinoma
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|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence that hOGG1 S326C genetic polymorphism was not associated with increased risk of gastric cancer.
|
22296498 |
2012 |
rs1052133
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Stomach Carcinoma
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|
0.100 |
GeneticVariation
|
BEFREE |
To clarify any association between the hOGG1 Ser326Cys polymorphism and susceptibility to gastric cancer.
|
22799296 |
2012 |
rs1052133
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Stomach Carcinoma
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|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the association between Ser326Cys human oxoguanine glycosylase 1 (hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori (H. pylori) eradication.
|
20845517 |
2010 |
rs1052133
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Stomach Carcinoma
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|
0.100 |
GeneticVariation
|
BEFREE |
Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study and a meta-analysis.
|
26600527 |
2015 |
rs1052133
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Stomach Carcinoma
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0.100 |
GeneticVariation
|
BEFREE |
hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations.
|
15596047 |
2004 |
rs1052133
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Stomach Carcinoma
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|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase (ADPRT, Val762Ala), 8-oxoguanine DNA glycosylase (OGG1, Ser326Cys) and apurinic/apyrimidinic endonuclease 1 (APE1, Asp148Glu) and evolution of H.pylori-associated precancerous gastric lesions, a population-based cohort study was conducted in Linqu County, a high-risk area of gastric cancer in China.
|
19147860 |
2009 |
rs1052133
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Stomach Carcinoma
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|
0.100 |
GeneticVariation
|
BEFREE |
No significant association was found for either allele or genotype with gastric cancer (odds ratio [OR]=0.96; 95% confidence interval [95% CI]: 0.82-1.13; P=0.66), and this was also the case after combining 326Ser/Cys and 326Ser/Ser genotypes together (OR=0.87; 95% CI: 0.63-1.20; P=0.40), or 326Cys/Cys and 326Ser/Cys together (OR=1.03; 95% CI: 0.87-1.22; P=0.72).
|
22471492 |
2011 |
rs1052133
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Stomach Carcinoma
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|
0.100 |
GeneticVariation
|
BEFREE |
We examined the distribution of the hOGG1 Ser326Cys polymorphism and its presumed correlation with gastric cancer risk in two case-control studies of different ethnic groups in São Paulo, Brazil.
|
11448535 |
2001 |
rs1052133
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Stomach Carcinoma
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0.100 |
GeneticVariation
|
BEFREE |
Although smokers and high salted tea drinkers themselves were at higher risk for gastric cancer (OR=8.975, P=0.0001; OR=14.778, P=0.0001), interaction with OGG1 Ser326Cys did not further modulate the risk.
|
20593951 |
2010 |
rs1052133
|
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis showed there was no association between hOGG1 rs1052133 and GC.
|
28415729 |
2017 |
rs1052133
|
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Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The significant effects of hOGG1 Ser326Cys polymorphism on colorectal, breast, bladder, prostate, esophageal, and gastric cancer were not detected.
|
22114677 |
2011 |
rs1052133
|
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our result could explain the association between hOGG1 Ser326Cys polymorphism and GC risk.
|
22294108 |
2012 |